Artemisinin

Artemisinin

CAS No.: 63968-64-9
Molecular Formula: C15H22O5
Molecular Weight: 282.33
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product description
Artemisinin is an antimalarial agent with anticancer activity. It is an iron(II) oxide-reactive endoperoxide that generates reactive oxygen species (ROS) upon cleavage of its endoperoxide bridge. It reduces the growth of various P. falciparum strains in vitro (IC50s = 3.98-20.36 nM) and reduces parasitemia in mice infected with P. falciparum with a curative dose (CD50) value of 140 mg/kg. It also reduces P. berghei infection in mice (ED50 = 5.6 mg/kg per day).


Chemical Properties

PropertyValue

Melting point

156-157 °C (lit.)

Alpha

76 º (c=0.5,MeOH)

Boiling point

344.94°C (rough estimate)

Density

1.0984 (rough estimate)

Refractive index

75 ° (C=0.5, MeOH)

Storage temp.

-20°C

Solubility

Soluble to 100mM in DMSO and to 75mM in ethanol

Form

White to off-white crystalline solid.

Color

Needles

Optical Rotation

[α]20/D +76°, c = 0.5 in methanol

Merck

14,817

Stability

Stable. Combustible. Incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides. May absorb, and react with, carbon dioxide from the air.

InChI

InChI=1S/C15H22O5/c1-8-4-5-11-9(2)12(16)17-13-15(11)10(8)6-7-14(3,18-13)19-20-15/h8-11,13H,4-7H2,1-3H3/t8-,9-,10+,11+,13-,14-,15-/m1/s1

InChIKey

BLUAFEHZUWYNDE-NNWCWBAJSA-N

SMILES

O1[C@]23[C@@]4([H])O[C@@](C)(CC[C@@]2([H])[C@H](C)CC[C@@]3([H])[C@@H](C)C(=O)O4)O1

LogP

2.900


Safety Information

PropertyProperty

Safety Statements

22-24/25

WGK Germany

2

RTECS

KD4170000

HS Code

29322985

Toxicity

LD50 in mice (mg/kg): 5105 orally; 2800 i.m.; 1558 i.p. (Koch); LD50 in mice, rats (mg/kg): 4228, 5576 orally; 3840, 2571 i.m. (China Cooperative Research Group on Qinghaosu)


Product Usage

Artemisinin, a sesquiterpene lactone extracted from the sweet wormwood plant (Artemisia annua), is globally recognized as the most effective treatment for malaria. Its primary application is in the pharmaceutical industry, where it serves as the core active ingredient in Artemisinin-based Combination Therapies (ACTs), the World Health Organization's gold standard for treating multi-drug resistant malaria. Beyond its antimalarial role, it is increasingly utilized in biomedical research for its promising anti-tumor activities, specifically its ability to induce apoptosis in various cancer cell lines. In the nutraceutical sector, artemisinin is featured in specialized dietary supplements aimed at supporting immune function and addressing parasitic imbalances. Furthermore, it acts as a critical chemical precursor for the semi-synthesis of potent derivatives like artemether and artesunate, which offer improved solubility and bioavailability for clinical use.

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Delivery Time

Inventory 2-3 working days New manufacturing 7-10 working days

Mode of Transportation
1. By Air, fast but expensive.
2. By Sea, usual and economy.
3. By Train, suit for middle Asia countries.
4. By Express, suit for small package.
We only provide highest quality goods available, accompanied by after support!

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Q1: Are Your Products Compliant With International Standards?

A1: Yes, our company holds a number of internationally recognized core certifications. All production and operation activities strictly follow international environmental, safety and quality standards, and each batch of products is accompanied by a compliance test report to meet the chemical industry requirements in different regions around the world.


Q2: Do You Provide Customized Product Services?
A2: Yes, we have a professional R&D team and refined production capacity. We can customize chemical products of different specifications and performances according to customers' specific needs, and provide full-process technical support to meet the personalized application needs of downstream industries.


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A3: The delivery cycle varies according to product type, order quantity and destination. We have a complete global supply chain system to ensure fast and safe delivery of goods. For specific cycle, you can consult our sales team for detailed information.


Q4: How To Obtain Product Samples?
A4: You can contact our customer service or sales team to specify the specific model and specification of the required samples. We will provide free samples according to the actual situation, and the sample express fee can be negotiated.

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