Pagoclone

Pagoclone

CAS No.: 133737-48-1
Molecular Formula: C23H22ClN3O2
Molecular weight: 407.89
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product description

Pagolone is a specific GABA (Gamma-aminobutyric acid) receptor modulator that can reduce stuttering. Pagolone is a novel cyclopyrrolone that acts as a partial GABA (A) receptor agonist.


Chemical Properties

PropertyValue

Boiling point

582.1±50.0 °C(Predicted)

density

1.273±0.06 g/cm3(Predicted)

pka

1.62±0.30(Predicted)

InChI

InChI=1S/ C23H22ClN3O2/ c1-14(2) 7-10-16(28) 13-19-17-5-3-4-6-18(17) 23(29) 27(19)21-12-9-15-8-11-20 (24) 25-22(15) 26-21/ h3-6,8-9,11-12, 14, 19H, 7,10, 13H2, 1-2H3

InChIKey

HIUPRQPBWVEQJJ-UHFFFAOYSA-N

SMILES

C1(=O)C2= C(C=CC=C2)C(CC(=O)CCC(C)C)N1C1= CC=C2C(=N1)N=C(Cl)C=C2


Product Usage

Pagoclone is a non-benzodiazepine anxiolytic compound belonging to the cyclopyrrolone family. As a selective GABA-A receptor partial agonist, its primary pharmaceutical application has been the focus of clinical research for treating generalized anxiety disorder (GAD) and panic disorders. Unlike traditional benzodiazepines, pagoclone is designed to provide anti-anxiety effects with significantly reduced sedative and amnestic side effects. Furthermore, it has gained international attention for its potential application in treating persistent developmental stuttering, with clinical trials exploring its ability to improve speech fluency. In the research sector, it serves as a critical reference standard for studying receptor subtype selectivity and the development of next-generation social ligands.

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Shipping And Transportation

Delivery Time

Inventory 2-3 working days New manufacturing 7-10 working days

Mode of Transportation
1. By Air, fast but expensive.
2. By Sea, usual and economy.
3. By Train, suit for middle Asia countries.
4. By Express, suit for small package.
We only provide highest quality goods available, accompanied by after support!

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Qualification Certificate
  • 微信图片_2026-04-09_153718_808
  • 微信图片_2026-04-09_153715_255
  • 微信图片_2026-04-09_153711_744
  • 微信图片_2026-04-09_153654_640
FAQ

Q1: Are Your Products Compliant With International Standards?

A1: Yes, our company holds a number of internationally recognized core certifications. All production and operation activities strictly follow international environmental, safety and quality standards, and each batch of products is accompanied by a compliance test report to meet the chemical industry requirements in different regions around the world.


Q2: Do You Provide Customized Product Services?
A2: Yes, we have a professional R&D team and refined production capacity. We can customize chemical products of different specifications and performances according to customers' specific needs, and provide full-process technical support to meet the personalized application needs of downstream industries.


Q3: What Is The Approximate Delivery Cycle Of The Products?
A3: The delivery cycle varies according to product type, order quantity and destination. We have a complete global supply chain system to ensure fast and safe delivery of goods. For specific cycle, you can consult our sales team for detailed information.


Q4: How To Obtain Product Samples?
A4: You can contact our customer service or sales team to specify the specific model and specification of the required samples. We will provide free samples according to the actual situation, and the sample express fee can be negotiated.

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